Key result
Caveolin-1 structure, signalling, and single nucleotide polymorphisms are highlighted as potential therapeutic targets in chronic kidney disease.
This review summarizes the structure and signaling of caveolin-1 and its potential as a therapeutic target in chronic kidney disease.
Should not yet change CKD practice; leaves open caveolin-1 as a therapeutic target pending trials.
Caveolin-1 is the essential structural formation for lipid raft formation. It has been ascribed to several disease processes in humans due to its ubiquitous distribution. Patients with chronic kidney disease suffer great morbidity and mortality where manipulation of caveolin-1 could lead to new potential therapeutic targets in this patient group. This review highlights caveolin-1 structure, signalling and provides examples of studies of caveolin-1 single nucleotide polymorphism in chronic kidney disease.
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Chand Sourabh (2018) conducted a review in Chronic kidney disease. Caveolin-1 was evaluated. Caveolin-1 structure, signalling, and single nucleotide polymorphisms are highlighted as potential therapeutic targets in chronic kidney disease.
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