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August 15, 2008Nephron Clinical PracticeOpen Access

Creatinine-based formulas for estimating glomerular filtration rate, such as the MDRD equation, have significant analytical and population-specific limitations that impact chronic kidney disease staging.

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Why the study?

What are the limitations of creatinine-based formulas like Cockcroft-Gault and MDRD in estimating glomerular filtration rate?

Population

Populations evaluated for chronic kidney disease, including healthy individuals and patients with abnormal…

Design

Review

Key result

Creatinine-based formulas for estimating glomerular filtration rate, such as the MDRD equation, have significant analytical and population-specific limitations that impact chronic kidney disease staging.

Authors

PDPierre DelanayeUniversity of LiègeECEric P. CohenNew York University

Discussion

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Overview

Clinicians should interpret MDRD-based CKD staging with caution; review leaves open need for better GFR estimators.

Structured PICO

What are the limitations of creatinine-based formulas like Cockcroft-Gault and MDRD in estimating glomerular filtration rate?

P
Population
Populations evaluated for chronic kidney disease, including healthy individuals and patients with abnormal weight (anorectic or obese)
I
Intervention
Creatinine-based formulas for estimating glomerular filtration rate (Cockcroft-Gault and MDRD equations)
O
Outcome
Precision and limitations of GFR estimation formulas

Physicians should be aware of the analytical and population-specific limitations of commonly used creatinine-based GFR estimation formulas like MDRD.

Limitations

  • MDRD formulas are not applicable to all populations, notably healthy individuals and patients with abnormal weight
  • Limitations in the precision of the formulas linked to analytical aspects

Cite This Study

Delanaye et al. (2008) conducted a review in Chronic kidney disease. Creatinine-based formulas (Cockcroft-Gault, MDRD) was evaluated. Creatinine-based formulas for estimating glomerular filtration rate, such as the MDRD equation, have significant analytical and population-specific limitations that impact chronic kidney disease staging.

synapsesocial.com/papers/6a1c2aabfc87fd06169d18c0https://doi.org/10.1159/000151436
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serum Creatinine as an Index of Renal Function: New Insights into Old Concepts1992 · 1,588 citations
  2. 2Prediction of Creatinine Clearance from Serum Creatinine1976 · 15,448 citations
  3. 3Staging of Chronic Kidney Disease2008 · 134 citations
  4. 4Estimating the Prevalence of Low Glomerular Filtration Rate Requires Attention to the Creatinine Assay Calibration2002 · 132 citations
  5. 5Estimated glomerular filtration rate as an end point in kidney transplant trial: where do we stand?2007 · 34 citations