Key result
Cockcroft-Gault and MDRD formulas correctly assigned only 64% and 62% of subjects, respectively, to their actual K/DOQI-CKD classification compared to measured GFR.
Why the study?
How accurate are creatinine-based eGFR formulas compared to measured GFR for classifying chronic kidney disease?
Population
Adults evaluated for chronic kidney disease
Comparison
Estimation of GFR using creatinine-based formulas vs Measured GFR (mGFR)
Design
Review
Authors
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Creatinine-based eGFR formulas misclassify over one-third of patients; leaves open whether measured GFR improves CKD staging accuracy.
How accurate are creatinine-based eGFR formulas compared to measured GFR for classifying chronic kidney disease?
Absolute Event Rate: 64% vs 62%
Creatinine-based eGFR formulas (Cockcroft-Gault and MDRD) misclassify a significant proportion of patients compared to measured GFR, highlighting the need for clinical caution in daily practice.
Botev et al. (2011) conducted a review in Chronic Kidney Disease. Cockcroft-Gault formula vs. MDRD formula was evaluated on Correct assignment to K/DOQI-CKD classification's GFR groups. Cockcroft-Gault and MDRD formulas correctly assigned only 64% and 62% of subjects, respectively, to their actual K/DOQI-CKD classification compared to measured GFR.
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