Key result
Higher Life's Simple 7 scores in 37,140 participants were strongly associated with lower white matter hyperintensity load and reduced microstructural white matter injury.
Why the study?
Associations of the American Heart Association Life's Simple 7 metric with macrostructural hyperintensities and microstructural white matter damage are unclear.
Are higher Life's Simple 7 scores associated with better cerebral white matter macrostructural and microstructural integrity in adults?
Cohort (n=37,140)
Are higher Life's Simple 7 scores associated with better cerebral white matter macrostructural and microstructural integrity in adults?
Healthier cardiovascular profiles, as measured by the Life's Simple 7 metric, are associated with better macrostructural and microstructural markers of brain health.
Supports cardiovascular health promotion for brain integrity; leaves open whether LS7 modification causally reduces white matter injury.
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Fu et al. (2023) reported a cohort. Life's Simple 7 (LS7) score was evaluated on White matter hyperintensity load (WMH) and diffusion imaging indices. Higher Life's Simple 7 scores in 37,140 participants were strongly associated with lower white matter hyperintensity load and reduced microstructural white matter injury.
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