Why the study?
Does aspirin reduce angioplasty-induced vessel wall hyperemia in dogs with experimentally dilated carotid arteries?
Does aspirin reduce angioplasty-induced vessel wall hyperemia in dogs with experimentally dilated carotid arteries?
Intravenous aspirin significantly attenuates the increase in vessel wall blood flow following experimental angioplasty in a canine model, suggesting a role for prostaglandins in angioplasty-induced hyperemia.
Aspirin attenuates post-dilation hyperemia in canines; leaves open relevance to human PCI and prostaglandin-targeted therapies.
Angioplasty produces a persistent 20-fold increase in blood flow through mural vasa vasorum. To assess the role of prostaglandins in this phenomenon, vessel wall blood flow in experimentally dilated carotid arteries of aspirin treated dogs was measured. Aspirin (10 mg/kg, intravenously) significantly attenuated the increase in blood flow produced by dilation (+283 +/- 91% SE, n = 6) when compared to non-aspirin-treated controls (+2356 +/- 885% SE, n = 10). This suggests that aspirin, by interfering with arachidonate metabolism, may decrease local vasodilation after angioplasty. The effect of aspirin therapy on the long-term success of angioplasty requires further study.
No takes yet. Share an insight, caveat, or question.
Cragg et al. (1983) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: