What does this research mean for the field?

The positive inotropic effect of endothelin-3 on mammalian ventricular myocardium varies widely across species, likely due to differences in the cellular coupling processes subsequent to phosphoinositide hydrolysis rather than receptor binding alone. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1997British Journal of PharmacologyOpen Access

Species‐dependent differences in inotropic effects and phosphoinositide hydrolysis induced by endothelin‐3 in mammalian ventricular myocardium

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Population

Ventricular muscles from the rat, guinea-pig, rabbit, ferret, and dog

Design

Preclinical

Authors

HYHuang‐Tian YangHeart Failure & Transplant YZYi ZhuTianjin Medical University MEMasao EndohYamagata University

Discussion

Member takes

Implication

Species variations in ET-3 inotropy caution against direct translational extrapolation; leaves open post-receptor coupling mechanisms in ventricular myocardium.

Structured PICO

Population

Ventricular muscles from the rat, guinea-pig, rabbit, ferret, and dog

Intervention

Endothelin-3 (ET-3) in the presence of (+/-)-bupranolol (0.3 microM) and prazosin (0.3 microM)

Outcome

Positive inotropic effect (PIE), specific binding of [125I]-ET-3, and accumulation of [3H]-inositol monophosphate (IP1)surrogate

There are wide species-dependent variations in the positive inotropic effect of endothelin-3 on mammalian ventricular muscles, likely due to variations in coupling processes subsequent to phosphoinositide hydrolysis.

Cite This Study

Yang et al. (1997) studied this question.

synapsesocial.com/papers/6a1c2f1b1567d2fc4d5fba11 https://doi.org/10.1038/sj.bjp.0701085

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Implication

Species variations in ET-3 inotropy caution against direct translational extrapolation; leaves open post-receptor coupling mechanisms in ventricular myocardium.

Species‐dependent differences in inotropic effects and phosphoinositide hydrolysis induced by endothelin‐3 in mammalian ventricular myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Species‐dependent differences in inotropic effects and phosphoinositide hydrolysis induced by endothelin‐3 in mammalian ventricular myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider