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September 1, 1988Proceedings of the National Academy of SciencesOpen Access

Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide.

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Population

Rat models (rat aortic strip, perfused rat heart, conscious rat)

Design

Preclinical

Authors

Masashi YanagisawaMasashi YanagisawaVascular MedicineAIAkihiro InoueEhime UniversityTITomohisa IshikawaKumamoto Orthopedic Surgery Hospital

Discussion

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Implication

Endothelin shows potent vasoconstriction in rat models; leaves open its role in human vascular disease.

Structured PICO

P
Population
Rat models (rat aortic strip, perfused rat heart, conscious rat)
I
Intervention
Synthetic rat endothelin
O
Outcome
Vasoconstrictor activity and in vivo pressor activitysurrogate

This study identifies the primary structure of rat endothelin and demonstrates its potent vasoconstrictor and pressor activities in rat models.

Cite This Study

Yanagisawa et al. (1988) studied this question.

synapsesocial.com/papers/6a7510ee33d16877c7f55dd7https://doi.org/10.1073/pnas.85.18.6964
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Also Consider

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  1. 1Variation of Plasma and Kidney Renin Activities Among Substrains of Spontaneously Hypertensive Rats1980 · 39 citations
  2. 2The Role of Endothelium in the Responses of Vascular Smooth Muscle to Drugs1984 · 937 citations
  3. 3In vitro polyoma DNA synthesis: inhibition by 1-beta-d-arabinofuranosyl CTP1975 · 24 citations
  4. 4Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin1988 · 401 citations
  5. 5DNA sequencing with chain-terminating inhibitors1977 · 69,520 citations