Key result
Hepatic fat is linked to pancreatic fat only in younger, cardiometabolically healthy adults.
Why the study?
Previous studies evaluating the association between hepatic fat and intrapancreatic fat deposition yielded inconclusive results, potentially due to cardiometabolic factors across subpopulations.
Do cardiometabolic factors moderate the association between hepatic fat and intrapancreatic fat deposition in adults?
Cross-Sectional (n=367)
No
Do cardiometabolic factors moderate the association between hepatic fat and intrapancreatic fat deposition in adults?
The association between hepatic fat and intrapancreatic fat deposition is present in younger adults with good cardiometabolic health but becomes uncoupled in older adults or those with cardiometabolic risk factors.
Should not guide clinical fat assessment in older or at-risk adults; leaves open prospective confirmation of moderation by age and cardiometabolic factors.
Objective Previous studies have investigated the association between hepatic fat and intrapancreatic fat deposition (IPFD); however, results have been inconclusive. The presence of cardiometabolic factors in certain subpopulations could explain this discrepancy. The aim of the present study was to use moderation analyses to determine the conditions under which hepatic fat is associated with IPFD. Methods All participants underwent 3T abdominal magnetic resonance imaging (MRI) and spectroscopy. Hepatic fat and IPFD were manually quantified by independent raters. Moderation analyses were performed with adjustment for sex and ethnicity. Results There were 367 participants included. Adjusted analyses of the overall cohort revealed that age, glycated hemoglobin (HbA 1c ), low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C), and triglycerides were significant moderators ( p < 0.05) of the association between hepatic fat and IPFD. Ranges of significance included age < 61 years, HbA 1c < 45 mmol/mol, LDL‐C < 157 mg/dL, HDL‐C > 36 mg/dL, and triglycerides < 203 mg/dL. Conclusions The association between hepatic fat and IPFD is generally present in young and middle‐aged adults with good cardiometabolic health, whereas the link between the two fat depots becomes uncoupled in older adults or individuals with cardiometabolic risk factors.
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Skudder‐Hill et al. (2024) conducted a cross-sectional in Hepatic and intrapancreatic fat deposition (n=367). Hepatic fat was evaluated on Moderation of the association between hepatic fat and intrapancreatic fat deposition by cardiometabolic factors (p=<0.05). The association between hepatic fat and intrapancreatic fat deposition is significant in adults aged <61 years with good cardiometabolic health, but is lost in older adults or those with cardiometabolic risk factors.
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