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April 13, 2023Journal of Digestive Diseases and HepatologyOpen Access

Predictors of Hepatic Fat Fraction Measured by Magnetic Resonance Imaging in Adults with Non-alcoholic Fatty Liver Disease

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Key result

Higher serum triglycerides are linked to increased hepatic fat fraction in adults with NAFLD.

  • P<0.05
  • n=47

Why the study?

Few studies have addressed whether clinical and metabolic abnormalities related to insulin resistance predict hepatic fat accumulation assessed by magnetic resonance imaging in patients with NAFLD.

Population

47 adults with overweight and NAFLD detected by abdominal sonography

Comparison

Association of IR-related clinical and biochemical abnormalities with hepatic fat fraction

Authors

DSDébora Gonçalves da SilvaAAAngélica Amorim Amato

Discussion

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Overview

Caution against changing NAFLD management; leaves open sex-specific mechanisms for prospective validation.

Study Design

Type

Cross-Sectional (n=47)

Multicenter

Yes

Structured PICO

P
Population
47 adults over 20 years of age with overweight or obesity and sonographic evidence of NAFLD were assessed cross-sectionally to identify predictors of hepatic fat fraction.
O
Outcome
Hepatic fat fraction (HFF) determined by chemical-shift magnetic resonance imagingsurrogate

Main Result

p-value: p=<0.05

Serum triglycerides and sex-specific insulin resistance markers predict hepatic fat fraction in adults with overweight/obesity and NAFLD.

Limitations

  • Small sample size
  • Cross-sectional design precludes establishing causality or long-term changes
  • Lack of histological assessment of steatohepatitis and fibrosis

Cite This Study

Silva et al. (2023) conducted a cross-sectional in Non-alcoholic fatty liver disease (NAFLD) (n=47). Insulin resistance-related biochemical abnormalities (e.g., serum triglycerides) vs. Lower levels of biochemical abnormalities was evaluated on Hepatic fat fraction (HFF) measured by chemical-shift MRI (p=<0.05). Higher serum triglyceride levels were associated with increased hepatic fat fraction in adults with NAFLD, while insulin resistance markers correlated with hepatic fat content in a sex-specific manner.

synapsesocial.com/papers/6aa450bb863f8286fa1d424dhttps://doi.org/10.29011/2574-3511.100090
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1T1-weighted dual-echo MRI for fat quantification in pediatric nonalcoholic fatty liver disease2011 · 79 citations
  2. 2Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population2004 · 1,581 citations
  3. 3Imaging evaluation of non-alcoholic fatty liver disease: focused on quantification2017 · 164 citations