Key result
Nonalcoholic fatty liver disease was associated with significantly higher pancreatic fat content compared to healthy controls (8.5% vs 3.6%, P<0.001).
Why the study?
Does pancreatic fat content differ between patients with NAFLD and healthy controls, and is it associated with insulin resistance?
Population
92 participants, including 43 patients with biopsy-proven nonalcoholic fatty liver disease and 49 healthy…
Design
Case-control
Authors
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Pancreatic fat may mark metabolic burden in NAFLD; leaves open causal role in insulin resistance.
Case-Control (n=92)
Does pancreatic fat content differ between patients with NAFLD and healthy controls, and is it associated with insulin resistance?
Absolute Event Rate: 8.5% vs 3.6%
p-value: p=<0.001
Patients with NAFLD have significantly greater pancreatic fat accumulation than healthy controls, which is strongly associated with insulin resistance and hepatic steatosis.
Patel et al. (2013) conducted a case-control in Nonalcoholic Fatty Liver Disease (n=92). Nonalcoholic fatty liver disease vs. Healthy controls was evaluated on Pancreatic fat content (MRI-PDFF) (p=<0.001). Nonalcoholic fatty liver disease was associated with significantly higher pancreatic fat content compared to healthy controls (8.5% vs 3.6%, P<0.001).
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