Key result
Elevated NT-proBNP and troponin T levels on admission strongly predicted 30-day all-cause mortality (OR 9.0 and OR 6.3, respectively; both p<0.001) in patients with COPD exacerbations.
Why the study?
Do elevated levels of NT-proBNP and troponin T predict 30-day mortality in patients admitted with acute exacerbations of COPD?
Population
Consecutive patients with physician-diagnosed COPD exacerbation but without clinical evidence of acute…
Comparison
Elevated NT-proBNP and/or elevated troponin T… vs Normal levels of NT-proBNP and troponin T
Design
Cohort
Follow-up
30 days
Authors
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May aid risk stratification in COPD exacerbations; hypothesis-generating for cardiac interventions, pending prospective validation.
Cohort (n=244)
No
Do elevated levels of NT-proBNP and troponin T predict 30-day mortality in patients admitted with acute exacerbations of COPD?
Effect estimate: OR 9.0 (95% CI 3.1 to 26.2)
p-value: p=<0.001
Elevated NT-proBNP and troponin T are strong, independent predictors of early mortality in patients admitted with acute exacerbations of COPD, suggesting subclinical cardiac involvement is a key prognostic determinant.
Chang et al. (2011) conducted a cohort in acute exacerbations of COPD (n=244). Elevated NT-proBNP and troponin T vs. Normal values was evaluated on all-cause mortality at 30 days (OR 9.0, 95% CI 3.1 to 26.2, p=<0.001). Elevated NT-proBNP and troponin T levels on admission strongly predicted 30-day all-cause mortality (OR 9.0 and OR 6.3, respectively; both p<0.001) in patients with COPD exacerbations.
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