Key result
Type 2 diabetes is linked to ~16% higher maximal left atrial volume index vs controls.
Why the study?
Cardiovascular complications threaten diabetic patients with diastolic dysfunction being the earliest change, making assessment of LA function key to detecting early heart damage.
Does diabetes mellitus affect left atrial volumes and functions in normotensive patients without symptomatic cardiovascular disease?
Case-Control (n=110)
No
Does diabetes mellitus affect left atrial volumes and functions in normotensive patients without symptomatic cardiovascular disease?
Absolute Event Rate: 23.55% vs 20.3%
p-value: p=<0.05
Real-time 3D echocardiography demonstrates that normotensive patients with type 2 diabetes have increased left atrial volume and impaired contractility, whereas those with type 1 diabetes exhibit only impaired contractility.
May indicate early LA remodeling in normotensive T2DM; leaves open prognostic value and need for prospective validation.
Background . Cardiovascular complications are the most serious threat to diabetic patients. Associated metabolic and microvascular changes are the main cause of cardiac function affection, and the earliest cardiac change is diastolic dysfunction. Assessment of LA function changes is a key to determine early heart damage of diabetic patients. Objectives . To evaluate the effect of diabetes mellitus on left atrial volumes and functions by using real-time 3-dimensional echocardiography in normotensive patients free from cardiovascular disease. Methods . The study included 110 individuals, 50 controls and 60 patients with diabetes mellitus, 30 patients with type 1 diabetes mellitus and 30 patients with type 2 diabetes mellitus. 2-dimensional echocardiography was used to assess the LA maximum volume and LA phasic volumes, and LA maximum volume indexed to body surface area were measured by 3D echocardiography. LA functions (LA total stroke volume, LA active stroke volume, and LA active emptying fraction) were obtained from RT3D volumetric analysis. Results . The results of the analysis revealed that type 2 diabetes mellitus showed enlargedVmax,Vmin, and LAVi with an increased LA total stroke volume and decreased active emptying fraction, while type 1 diabetics showed only decreased in active emptying fraction. The LA maximum volume indexed to body surface area (LAVi) was significantly higher in type 2 diabetic patients as compared to normal controls which was23.55±3.37 ml/m2versus 20.30. Conclusion . Patients with type 2 diabetes mellitus have an increased LA volume with impaired compliance and contractility, while patients with type 1 diabetes mellitus have only impaired contractility compared to nondiabetic subjects.
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Hamza et al. (2020) conducted a case-control in Diabetes Mellitus (n=110). Type 2 Diabetes Mellitus vs. Healthy controls was evaluated on Left atrial maximum volume indexed to body surface area (LAVi) (p=<0.05). Type 2 diabetes mellitus was associated with a significantly higher left atrial maximum volume indexed to body surface area compared to normal controls (23.55 vs 20.30 ml/m2).
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