Population
Transgenic mice overexpressing phospholamban, gene-targeted mice without phospholamban, and isogenic…
Comparison
Genetic overexpression or knockout of… vs Isogenic wild-type control mice
Design
Preclinical
Authors
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Phospholamban levels determine in vivo force-frequency relations in mice; extends prior mechanistic data but leaves open human translation.
Phospholamban levels act as a critical negative determinant of the force-frequency relation and myocardial contractility in vivo.
Kadambi et al. (1999) studied this question.
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