Key result
Vascular adventitia calcification was observed in 50% of human samples and 10% of ApoE-/- mice, and in vitro experiments demonstrated it may arise from fibroblasts transformed into myofibroblasts.
Absolute Event Rate: 40.4% vs 9.3%
p-value: p=<0.01
This study provides novel histological and in vitro evidence that vascular calcification can occur in the adventitia, likely driven by the phenotypic conversion of adventitial fibroblasts into myofibroblasts.
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Adventitial calcification may warrant consideration in vascular assessment; leaves open its prevalence and fibroblast-driven mechanism in humans.
Li et al. (2015) studied Vascular calcification (n=83). TGF-β1 + mineralization media (in vitro) vs. Control media was evaluated on α-actin positive cells (phenotype conversion of fibroblasts into myofibroblasts) (p=<0.01). Vascular adventitia calcification was observed in 50% of human samples and 10% of ApoE-/- mice, and in vitro experiments demonstrated it may arise from fibroblasts transformed into myofibroblasts.
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