What does this research mean for the field?

Enhanced gene expression of apolipoprotein E (apoE) and lipoprotein lipase (LPL) increases cellular proteoglycan production by increasing the length of glycosaminoglycan chains. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2000Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

The Heparin-Binding Proteins Apolipoprotein E and Lipoprotein Lipase Enhance Cellular Proteoglycan Production

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Population

Two apoE-expressing cells (macrophages and fibroblasts) and LPL-expressing Chinese hamster ovary (CHO) cells

Comparison

Expression of apolipoprotein E or lipoprotein… vs Control cells

Design

Preclinical

Follow-up

up to 20 hours

Authors

JOJoseph C. ObunikeNew York University SPSivaram PillarisettiRush University Medical Center LPLatha PakaAngion (United States)

Discussion

Member takes

Implication

May influence arterial atherogenicity; hypothesis-generating from cellular data, requires in vivo validation.

Structured PICO

Population

Two apoE-expressing cells (macrophages and fibroblasts) and LPL-expressing Chinese hamster ovary (CHO) cells

Intervention

Expression of apolipoprotein E (apoE) or lipoprotein lipase (LPL)

Comparator

Control cells

Outcome

Proteoglycan (PG) production in medium, pericellular, and intracellular poolssurrogate

Enhanced gene expression of apoE and LPL increases cellular proteoglycan production, which may affect the atherogenic potential of arteries.

Cite This Study

Obunike et al. (2000) studied this question.

synapsesocial.com/papers/6a1c42bc4ebd09f3dfa9a226 https://doi.org/10.1161/01.atv.20.1.111

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