Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 1, 1991Journal of Biological ChemistryOpen Access

Apolipoprotein E gene expression in mouse 3T3-L1 adipocytes and human adipose tissue and its regulation by differentiation and lipid content

View Full Paper
Ask AI
Bookmark
Share

Population

Mouse 3T3-L1 adipocytes and human adipose tissue biopsies

Comparison

Differentiation, lipid content modulation, and… vs Undifferentiated 3T3-L1 preadipocytes and…

Design

Preclinical

Authors

RZRudolf ZechnerRMRosita MoserTNThomas C. Newman

Discussion

Loading...

Member takes

Overview

Adipocyte apoE responds to lipid loading independently of LPL; leaves open coordinated roles in human adipose tissue or cardiometabolic risk.

Structured PICO

P
Population
Mouse 3T3-L1 adipocytes and human adipose tissue biopsies
I
Intervention
Differentiation, lipid content modulation (biotin deprivation, cholesterol loading), and human recombinant tumor necrosis factor
C
Comparator
Undifferentiated 3T3-L1 preadipocytes and untreated cells
O
Outcome
Apolipoprotein E (apoE) mRNA and protein expressionsurrogate

ApoE and LPL are both expressed in adipocytes in a differentiation-dependent manner, but they are not coordinately regulated, as apoE expression is specifically responsive to cellular lipid and cholesterol content.

Cite This Study

Zechner et al. (1991) studied this question.

synapsesocial.com/papers/6a71877cac440176ef2a315ahttps://doi.org/10.1016/s0021-9258(18)99263-x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation, and evolution.1989 · 196 citations
  2. 2Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.1988 · 267 citations
  3. 3Identification and characterization of transcriptional regulatory regions associated with expression of the human apolipoprotein E gene.1988 · 73 citations
  4. 4The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding.1983 · 222 citations
  5. 5Synthesis, intracellular processing, and signal peptide of human apolipoprotein E.1984 · 192 citations