Population
Human hepatoma cell line HepG2
Comparison
Incubation with lipogenic factors vs Incubation without lipogenic factors
Design
Preclinical
Authors
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ApoE secretion independent of apoB in hepatocytes; hypothesis-generating for lipoprotein regulation and requires in vivo confirmation before any clinical consideration.
In HepG2 cells, the synthesis and secretion of apolipoprotein E occur independently of the production of apolipoprotein B-containing lipoproteins.
Fazio et al. (1992) studied this question.
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