What does this research mean for the field?

Cardiac myosin isoforms V1 and V3 generate similar unitary displacement and force amplitudes, but the duration of these mechanical events is significantly longer for V3 than for V1. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

June 1, 1998Circulation ResearchOpen Access

Comparison of Unitary Displacements and Forces Between 2 Cardiac Myosin Isoforms by the Optical Trap Technique

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Structured PICO

Population

Rat cardiac myosin isoforms V1 and V3

Intervention

Optical trap technique to measure actin-myosin interaction in the presence of low ATP concentration (0.5 micromol/L)

Comparator

Comparison between V1 and V3 isoforms

Outcome

Unitary displacements and forces (amplitude and duration)surrogate

Rat cardiac myosin isoforms V1 and V3 exhibit similar unitary displacement and force amplitudes but differ in duration, providing a molecular basis for the higher tension cost observed in V1-predominant muscles.

Discussion

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Implication

Supports molecular basis for isoform-dependent tension cost in rodent hearts; leaves open translation to human myocardium.

Cite This Study

Sugiura et al. (1998) studied this question.

synapsesocial.com/papers/6a1c45b6ea84844e355faba8 https://doi.org/10.1161/01.res.82.10.1029

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Comparison of Unitary Displacements and Forces Between 2 Cardiac Myosin Isoforms by the Optical Trap Technique

Structured PICO

Discussion

Implication

Cite This Study

Comparison of Unitary Displacements and Forces Between 2 Cardiac Myosin Isoforms by the Optical Trap Technique

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider