Why the study?
Does thyroxine-induced alteration of myosin isozymes affect the velocity of papillary muscle shortening in rabbits?
Population
Male New Zealand rabbits, ages 4-24 weeks (n=30 initially, 16 analyzed)
Comparison
Thyroxine 150 micrograms/kg injected daily for 7… vs Equivalent volume of saline injected daily for 7…
Design
Preclinical
Follow-up
7 days
Authors
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Caution against clinical extrapolation from rabbit models; leaves open myosin isoform effects on human cardiac mechanics.
Does thyroxine-induced alteration of myosin isozymes affect the velocity of papillary muscle shortening in rabbits?
Changes in the relative amounts of myosin isozymes (specifically V1 vs V3) are responsible for sustained alterations in the speed of cardiac papillary muscle shortening.
Pagani et al. (1984) studied this question.
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