The relationship between alpha-MHC content and myocardial functional parameters is linear in adult rats but deviates in newborn and young rats, suggesting variations in specific myosin activity or undetected isomyosins during postnatal development.
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Caution against extrapolating adult rat myosin relations to neonates; leaves open translational relevance to human myocardium.
Cappelli et al. (1989) studied this question.