Key result
cAMP increased total myosin ATPase and V1 activity but inhibited V3 activity in rat hearts, an effect that disappeared with V1 depletion post-thyroidectomy but was restored by thyroid hormone.
Population
Rat hearts from animals of different ages and with different levels of thyroid function
Comparison
cAMP exposure and thyroid hormone injection vs Absence of cAMP / different thyroid states
Design
Preclinical
Authors
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Does not yet alter clinical management; leaves open whether rat cAMP-thyroid ATPase effects translate to humans.
This study demonstrates that cAMP differentially regulates myosin ATPase isozymes V1 and V3 in rat hearts, an effect dependent on thyroid hormone status.
Winegrad et al. (1987) studied Thyroid function and age-related changes in rat heart. cAMP and thyroid hormone was evaluated on Myosin ATPase activity. cAMP increased total myosin ATPase and V1 activity but inhibited V3 activity in rat hearts, an effect that disappeared with V1 depletion post-thyroidectomy but was restored by thyroid hormone.
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