What does this research mean for the field?

The SH1 thiols of cardiac myosin are essential for the thyroxine-induced increase in actin-activated ATPase activity, which likely drives the altered contractile properties of the thyrotoxic heart. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1977Circulation ResearchOpen Access

Actin-activated adenosine triphosphatase activity of native and N-ethylmaleimide-modified cardiac myosin from normal and thyrotoxic rabbits.

View Full Paper

Ask AI

Bookmark

Population

Cardiac myosin from euthyroid (myosin-N) and thyrotoxic (myosin-T) rabbits

Comparison

N-ethylmaleimide (NEM) modification of SH1 thiols vs Unmodified myosin-N and myosin-T

Design

Preclinical

Authors

SBS. K. BanerjeeBidhan Chandra Krishi Viswavidyalaya EMEugene MorkinUniversity of Arizona

Discussion

Member takes

Implication

Does not support practice changes in hyperthyroidism; leaves open whether SH1 thiols drive human cardiac myosin changes.

Structured PICO

Population

Cardiac myosin from euthyroid (myosin-N) and thyrotoxic (myosin-T) rabbits

Intervention

N-ethylmaleimide (NEM) modification of SH1 thiols

Comparator

Unmodified myosin-N and myosin-T

Outcome

Actin-activated ATPase activity (Vmax and Kapp)surrogate

SH1 thiols are essential to the increased actin-activated ATPase activity of cardiac myosin in thyrotoxicosis, suggesting thyroxine-induced enzymatic changes alter heart contractile properties.

Cite This Study

Banerjee et al. (1977) studied this question.

synapsesocial.com/papers/6a17ef46e3353ce899b3fd58 https://doi.org/10.1161/01.res.41.5.630

View Full Paper

Ask AI

Bookmark

Actin-activated adenosine triphosphatase activity of native and N-ethylmaleimide-modified cardiac myosin from normal and thyrotoxic rabbits.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Actin-activated adenosine triphosphatase activity of native and N-ethylmaleimide-modified cardiac myosin from normal and thyrotoxic rabbits.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider