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September 1, 1995AJP Cell Physiology

Maximum speed of shortening and ATPase activity in atrial and ventricular myocardia of hyperthyroid rats

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Population

Rats with induced hyperthyroidism

Comparison

Atrial myocardium preparations vs Ventricular myocardium preparations

Design

Preclinical

Follow-up

2 weeks

Authors

RBRoberto BottinelliHeart Failure / CardiomyopathyMCMonica CanepariUniversity of PaviaVCV. CappelliUniversity of Milan

Discussion

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Implication

Does not support clinical translation; leaves open myosin light chain isoforms as determinants of atrial-ventricular velocity differences in hyperthyroid models.

Structured PICO

P
Population
Rats with induced hyperthyroidism (daily subcutaneous injections of triiodothyronine 0.2 mg/kg body wt for 2 wk)
I
Intervention
Atrial myocardium preparations (skinned trabeculae and purified myofibrils)
C
Comparator
Ventricular myocardium preparations
O
Outcome
ATPase activity and maximum shortening velocitysurrogate

In hyperthyroid rats, the difference in maximum speed of shortening between atrial and ventricular myocardium may be due to tissue-specific isoforms of myosin light chains, as ATPase activity and myosin heavy chain isoforms are equal.

Cite This Study

Bottinelli et al. (1995) studied this question.

synapsesocial.com/papers/6a84305f2327ba91ab8d77abhttps://doi.org/10.1152/ajpcell.1995.269.3.c785
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