Why the study?
Does intravenous cocaine induce platelet activation in chronically instrumented, conscious dogs?
Population
Chronically instrumented, conscious dogs
Comparison
Intravenous cocaine infused over 1 minute vs Intravenous norepinephrine or saline infused…
Design
Preclinical
Follow-up
32 minutes
Authors
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Supports direct cocaine-induced platelet activation in vivo; leaves open translation to human thrombosis risk.
Does intravenous cocaine induce platelet activation in chronically instrumented, conscious dogs?
Intravenous cocaine induces delayed platelet activation in vivo, independent of its hemodynamic effects, suggesting a mechanism for cocaine-associated thrombosis.
Kugelmass et al. (1995) studied this question.
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