Key result
Cocaine (10 microM to 13 mM) added to whole blood induced significant increases in platelet-associated fibrinogen (45% to 125% increase) and P-selectin expression (36% to 112% increase).
Why the study?
Does cocaine induce activation of human platelets in whole blood?
Population
Human whole blood and platelets from donors
Comparison
Cocaine (concentrations of 10 microM to 13 mM) vs Buffer or plasma
Design
Preclinical
Authors
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Cocaine may promote thrombosis via platelet activation; this Level 5 evidence leaves open in vivo clinical relevance.
Does cocaine induce activation of human platelets in whole blood?
Cocaine induces platelet activation and enhances platelet response to physiological agonists, providing a potential mechanism for cocaine-associated coronary and peripheral thrombosis.
Kugelmass et al. (1993) studied this question. Cocaine was evaluated on Platelet-associated fibrinogen and P-selectin expression. Cocaine (10 microM to 13 mM) added to whole blood induced significant increases in platelet-associated fibrinogen (45% to 125% increase) and P-selectin expression (36% to 112% increase).
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