Key result
Depressive symptoms, hostility, and anger expression were positively associated with estimated insulin resistance, insulin, and glucose in healthy nondiabetic women, but not in men.
Why the study?
Are depressive symptoms, hostility, and anger expression associated with indices of glucose metabolism in healthy nondiabetic adults, and does gender moderate this association?
Cross-Sectional (n=135)
Are depressive symptoms, hostility, and anger expression associated with indices of glucose metabolism in healthy nondiabetic adults, and does gender moderate this association?
In healthy nondiabetic women, but not men, depressive symptoms, hostility, and anger expression are positively associated with insulin resistance and elevated fasting insulin and glucose, potentially mediating increased cardiovascular risk.
Suggests sex-specific psychometabolic links in nondiabetic adults; hypothesis-generating and should not yet change practice.
This study examined the relation of depressive symptomatology, hostility, and anger expression to indices of glucose metabolism and tested whether gender moderates these associations in a sample of 135 healthy, nondiabetic adults (75 men, 60 women). The severity of depressive symptoms, hostility, and anger expression was positively associated with estimated insulin resistance (IR) and insulin in women but not in men. Anger expression was positively associated with glucose in women only. A summary score of depressive symptoms, hostility, and anger expression was positively associated with estimated IR, insulin, and glucose in women but not in men. Hence, in women, IR and elevated levels of fasting insulin and glucose may be one pathophysiological mechanism mediating the increased risk of cardiovascular disease and Type 2 diabetes associated with these psychological attributes.
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Edward C. Suarez (2006) conducted a cross-sectional in Healthy, nondiabetic adults (n=135). Depressive symptoms, hostility, and anger expression vs. Men was evaluated on Indices of glucose metabolism (estimated insulin resistance, insulin, and glucose). Depressive symptoms, hostility, and anger expression were positively associated with estimated insulin resistance, insulin, and glucose in healthy nondiabetic women, but not in men.
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