What does this research mean for the field?

Creatine kinase M and B subunits exist as distinct basic and acidic subspecies that are coordinately synthesized during myogenesis and likely arise from multiple closely related genes rather than post-translational phosphorylation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1981European Journal of BiochemistryOpen Access

Occurrence of Heterogenous Forms of the Subunits of Creatine Kinase in Various Muscle and Nonmuscle Tissues and Their Behaviour during Myogenesis

View Full Paper

Ask AI

Bookmark

Population

Chicken and rat tissues and cell-free protein-synthesizing system

Design

Preclinical

Authors

URUrs B. RosenbergMax Planck Society HEHans M. EppenbergerHeart Failure / Cardiomyopathy JPJean‐Claude PerriardUniversité Claude Bernard Lyon 1

Discussion

Member takes

Implication

Multiple CK genes indicated in myogenesis; leaves open human cardiac isoform significance.

Structured PICO

Population

Chicken and rat tissues (myogenic cells, fast muscle, slow muscle, heart, gizzard, brain) and cell-free protein-synthesizing system

Intervention

Two-dimensional gel analysis, immunoreplicas, immunoprecipitations, coelectrophoresis, peptide mapping, and in vitro translation

Outcome

Identification and characterization of basic and acidic subspecies of M-creatine kinase and B-creatine kinase subunitssurrogate

The study identifies basic and acidic subspecies of creatine kinase subunits in various tissues, suggesting the existence of multiple closely related genes rather than post-translational modifications like phosphorylation.

Cite This Study

Rosenberg et al. (1981) studied this question.

synapsesocial.com/papers/6a1c47cf5b8f4ede65a9bfb9 https://doi.org/10.1111/j.1432-1033.1981.tb05304.x

View Full Paper

Ask AI

Bookmark

Occurrence of Heterogenous Forms of the Subunits of Creatine Kinase in Various Muscle and Nonmuscle Tissues and Their Behaviour during Myogenesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Occurrence of Heterogenous Forms of the Subunits of Creatine Kinase in Various Muscle and Nonmuscle Tissues and Their Behaviour during Myogenesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider