Key result
In chicken skeletal muscle, MM-creatine kinase is localized exclusively at the M-line, while B-type creatine kinase is found at the Z-line, suggesting MM-CK is an integral element of the M-line.
Population
Chicken skeletal muscle myofibrils (adult and early developmental stages)
Design
Preclinical
Authors
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Animal data on MM-CK localization require mammalian validation before cardiac translation; leaves open isoform roles in human myocardium.
The study demonstrates that MM-CK is specifically localized at the M-line of skeletal myofibrils, acting as an integral structural element capable of regenerating ATP during muscle contraction.
Wallimann et al. (1977) studied this question. Creatine kinase isoenzymes localization was evaluated on Localization of CK isoenzymes in myofibrils. In chicken skeletal muscle, MM-creatine kinase is localized exclusively at the M-line, while B-type creatine kinase is found at the Z-line, suggesting MM-CK is an integral element of the M-line.