March 1, 1985Molecular and Cellular Biology
Regulation of Creatine Kinase Induction in Differentiating Mouse Myoblasts
Population
MM14 mouse myoblasts
Design
Preclinical
Follow-up
48 hours
Authors
Discussion
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Member takes
Implication
Highlights mRNA-level CK control in myoblast differentiation; leaves open translation to human cardiac muscle.
Structured PICO
P
Population
MM14 mouse myoblasts
I
Intervention
Mitogen-depleted medium (to induce differentiation)
O
Outcome
Creatine kinase (CK) induction (enzymatic activity and mRNA levels)surrogate
The study demonstrates that creatine kinase induction during mouse myoblast differentiation is regulated at the mRNA level, with significant increases in M-CK mRNA and enzymatic activity following mitogen withdrawal.
Cite This Study
Chamberlain et al. (1985) studied this question.