Key result
De novo aortic insufficiency developed in 25% of patients during LVAD support, with continuous-flow pumps (HR 2.2) and closed aortic valves (OR 4.7) as significant predictors.
Why the study?
What is the incidence and what are the predictors of de novo aortic insufficiency in patients receiving left ventricular assist device support?
Systematic Review (n=657)
What is the incidence and what are the predictors of de novo aortic insufficiency in patients receiving left ventricular assist device support?
De novo aortic insufficiency is a common complication during LVAD support, particularly associated with continuous-flow devices, older age, and a closed aortic valve, though it did not significantly impact survival in this review.
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Warrants enhanced echocardiographic surveillance in continuous-flow LVAD patients with closed valves; extends meta-analytic evidence on de novo AI risk.
Deo et al. (2014) conducted a systematic review in Left ventricular assist device (LVAD) support (n=657). Left ventricular assist device (LVAD) was evaluated on Incidence of aortic insufficiency (95% CI 11-42). De novo aortic insufficiency developed in 25% of patients during LVAD support, with continuous-flow pumps (HR 2.2) and closed aortic valves (OR 4.7) as significant predictors.
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