Key result
Four-dimensional speckle tracking echocardiography showed patients with HCM had lower longitudinal (-13.5% vs -20.3%, P<0.001) and radial strain, but higher circumferential strain than controls.
Why the study?
Does four-dimensional speckle tracking echocardiography identify abnormal left ventricular deformational mechanics in patients with nonobstructive hypertrophic cardiomyopathy compared to healthy controls?
Case-Control (n=50)
Does four-dimensional speckle tracking echocardiography identify abnormal left ventricular deformational mechanics in patients with nonobstructive hypertrophic cardiomyopathy compared to healthy controls?
Absolute Event Rate: -13.5% vs -20.3%
p-value: p=<0.001
4DSTE demonstrates that patients with nonobstructive HCM have reduced longitudinal and radial strain but increased circumferential and area strain compared to healthy controls.
May aid detection of subclinical LV dysfunction in nonobstructive HCM; leaves open prognostic value and clinical adoption.
OBJECTIVE: Abnormal left ventricular (LV) deformational mechanics have been demonstrated in patients with hypertrophic cardiomyopathy (HCM) using two-dimensional (2D) speckle tracking echocardiography, but there is not enough information about the four-dimensional speckle tracking echocardiography (4DSTE) in these patients. The objective of the study was to identify and quantify the left ventricular contractility in patients with HCM using 4DSTE. METHODS: Thirty patients [age, 54.6 ± 12.1 years; 12 (40%) women] with diagnosis of nonobstructive HCM and 20 healthy controls [age, 47.42 ± 11.43 years; 8 (40%) women] underwent 4DSTE measurement of longitudinal, radial, circumferential, and area strains. RESULTS: Patients with HCM showed lower longitudinal (-13.5% vs. -20.3%, P < 0.001) and radial (33.4% vs. 43.6%, P < 0.001) strain, but higher circumferential (-22.7% vs. -15.9%, P < 0.001) and area (-30.7% vs. -22.1%, P < 0.001) strain than control subjects. Peak LV twist showed significantly higher values in patients with HCM (13.7 ± 5.3 vs. 11.3 ± 4.8, P < 0.005). CONCLUSIONS: Patients with HCM have reduced longitudinal and radial strain but increased circumferential and area strain on 4DSTE. These results are found appropriate with previous 2DSTE studies. Thus, 4DSTE is useful to determine LV deformational mechanics.
No takes yet. Share an insight, caveat, or question.
Kılıçkesmez et al. (2015) conducted a case-control in Hypertrophic Cardiomyopathy (n=50). Four-dimensional speckle tracking echocardiography (4DSTE) vs. Healthy controls was evaluated on Longitudinal strain (p=<0.001). Four-dimensional speckle tracking echocardiography showed patients with HCM had lower longitudinal (-13.5% vs -20.3%, P<0.001) and radial strain, but higher circumferential strain than controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: