What question did this study set out to answer?

To analyze heredity patterns of familial amyloidotic polyneuropathy (FAP) in Swedish patients.

Familial amyloidotic polyneuropathy in Sweden: a pedigree analysis.

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Extended genealogical analysis uncovers hereditary patterns and onset ages in Swedish FAP patients.

To analyze heredity patterns of familial amyloidotic polyneuropathy (FAP) in Swedish patients.
Performed extended genealogical studies using historical archives.
Included analysis of 239 patients linked to large and small pedigrees.
Investigated differences in ages of onset within and between pedigrees.
Identified five large pedigrees and 30 smaller families among 239 patients.
Found variation in mean ages of onset, with later onset in older generations.
Observed anticipation in age of onset in descendants of affected mothers compared to fathers.

Drugge et al. (1993) studied this question.

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