What does this research mean for the field?

Myosin V exhibits a high duty cycle of at least 50% and a large unitary working stroke of 20 nm, properties that enable processive organelle transport by a small number of molecules. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

November 12, 2001The Journal of Cell BiologyOpen Access

Myosin V exhibits a high duty cycle and large unitary displacement

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Structured PICO

Population

Heavy meromyosin-like fragments of murine myosin V (M5(HMM)) expressed in the Baculovirus system

Intervention

Laser trap and in vitro motility assay

Comparator

Smooth muscle myosin II (used for comparison in some assays)

Outcome

Duty cycle and unitary displacement (working stroke size)

Myosin V has a high duty cycle and large working stroke, consistent with its role as an organelle transporter and the lever arm model of myosin motion generation.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports myosin V processivity in transport; leaves open translation to mammalian physiology.

Cite This Study

Moore et al. (2001) studied this question.

synapsesocial.com/papers/6a1c4c3f26cb5670aa9da4f4 https://doi.org/10.1083/jcb.200103128

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Myosin V exhibits a high duty cycle and large unitary displacement

Structured PICO

Discussion

Implication

Cite This Study

Myosin V exhibits a high duty cycle and large unitary displacement

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider