Key result
Human myosin Vc is a low duty ratio (~10%), nonprocessive molecular motor whose rate-limiting step is the release of inorganic phosphate rather than ADP.
Human myosin Vc is a low duty ratio, nonprocessive molecular motor whose duty ratio may be regulated by physiological ADP concentrations.
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Should not yet change clinical practice; leaves open ADP regulation of myosin Vc duty ratio in human physiology.
Takagi et al. (2008) studied this question. Human Myosin Vc construct was evaluated on Steady-state actin-activated ATPase measurements and kinetic rates. Human myosin Vc is a low duty ratio (~10%), nonprocessive molecular motor whose rate-limiting step is the release of inorganic phosphate rather than ADP.
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