What question did this study set out to answer?

To evaluate total radical-trapping antioxidant parameter (TRAP) by direct measurement and mathematical calculation to assess systemic oxidative stress in patients with non-insulin-dependent diabetes mellitus.

February 1, 1997Diabetes Care

Total Radical-Trapping Antioxidant Parameter in NIDDM Patients

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To evaluate total radical-trapping antioxidant parameter (TRAP) by direct measurement and mathematical calculation to assess systemic oxidative stress in patients with non-insulin-dependent diabetes mellitus.
Measured plasma levels of malondialdehyde (MDA), directly measured TRAP (TRAPm), calculated TRAP (TRAPc), protein-bound SH groups, uric acid, vitamin E, and vitamin C.
Enrolled 40 NIDDM patients and 40 matched normal control subjects.
Both TRAPm and TRAPc were significantly reduced in diabetic patients compared with controls, demonstrating strong correlations between measured and calculated values in diabetic patients (r = 0.68, P < 0.0001) and healthy controls (r = 0.74, P < 0.0001).
Protein-bound SH groups and uric acid levels were significantly lower in diabetic subjects, whereas vitamin E was significantly higher even after correction for serum cholesterol.
Serum MDA was initially higher in diabetic patients but lost statistical significance following correction for serum triglycerides, while vitamin C levels did not differ between groups.

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Implication

Case-control study reveals decreased total radical-trapping antioxidant parameters in type 2 diabetes patients, suggesting impaired circulating antioxidant defenses.

Cite This Study

Ceriello et al. (1997) studied this question.

synapsesocial.com/papers/6a1c4cdbbc71fb1015a966ed https://doi.org/10.2337/diacare.20.2.194

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Implication

Case-control study reveals decreased total radical-trapping antioxidant parameters in type 2 diabetes patients, suggesting impaired circulating antioxidant defenses.

Total Radical-Trapping Antioxidant Parameter in NIDDM Patients

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Discussion

Implication

Cite This Study

Total Radical-Trapping Antioxidant Parameter in NIDDM Patients

Key Points

Discussion

Implication

Cite This Study

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