Key result
Neuro-cardiac junctions mediate fast chronotropic and inotropic effects and control tropic processes, with changes in cardiac adrenergic neurotransmission contributing to pathology progression.
Why the study?
To systematize and summarize experimental evidence supporting the hypothesis about cardiac quasi-synaptic transmission via neuro-cardiac junctions.
This review highlights the critical role of neuro-cardiac junctions in sympathetic regulation of the heart and their contribution to the progression of cardiovascular pathologies.
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May inform therapies targeting neuro-cardiac junctions; leaves open clinical validation in cardiovascular disease.
Odnoshivkina et al. (2021) conducted a review in Cardiac regulation and pathologies (heart failure, arrhythmias, hypertension). Neuro-cardiac junctions (NCJs) was evaluated. Neuro-cardiac junctions mediate fast chronotropic and inotropic effects and control tropic processes, with changes in cardiac adrenergic neurotransmission contributing to pathology progression.
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