Key result
Nitric oxide, natriuretic peptides, and neuropeptide Y act as local cardiac neuromodulators converging on neuronal cyclic nucleotide-dependent pathways to alter autonomic phenotype.
Design
Review
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Suggests neuromodulatory targets in HF and MI; leaves open need for interventional trials before clinical translation.
Local cardiac neuromodulators such as nitric oxide, natriuretic peptides, and neuropeptide Y play a significant role in altering the autonomic phenotype in both health and disease states like myocardial infarction and heart failure.
Herring et al. (2008) conducted a review in Myocardial infarction and congestive heart failure. Neuromodulators (nitric oxide, natriuretic peptides, neuropeptide Y) was evaluated. Nitric oxide, natriuretic peptides, and neuropeptide Y act as local cardiac neuromodulators converging on neuronal cyclic nucleotide-dependent pathways to alter autonomic phenotype.
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