Key result
Co-presence of neuropeptide Y enhanced the hypertrophic effect of norepinephrine on adult rat cardiomyocytes, increasing protein synthesis by 44% and cell volume from +6.4% to +18.2%.
Why the study?
Does neuropeptide Y enhance the hypertrophic response to norepinephrine in isolated adult rat ventricular cardiomyocytes?
Does neuropeptide Y enhance the hypertrophic response to norepinephrine in isolated adult rat ventricular cardiomyocytes?
Neuropeptide Y modulates and enhances the hypertrophic response of adult ventricular cardiomyocytes to norepinephrine, suggesting a role for co-released NPY from intramural nerve endings in cardiac hypertrophy.
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NPY may potentiate adrenergic cardiomyocyte hypertrophy; hypothesis-generating in rodents and requires human validation before clinical relevance.
M Kanevskij (2002) studied Hypertrophic response. Neuropeptide Y (NPY) + Norepinephrine vs. Norepinephrine alone was evaluated on Hypertrophic growth (cell volume, cross-sectional area, protein mass, protein and RNA synthesis). Co-presence of neuropeptide Y enhanced the hypertrophic effect of norepinephrine on adult rat cardiomyocytes, increasing protein synthesis by 44% and cell volume from +6.4% to +18.2%.
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