Key result
WiSE-CRT linked to improved diastolic function and mitral regurgitation severity at 6 months versus baseline.
Why the study?
While the impact of the WiSE-CRT system on LV volumes and systolic function has been published, its effect on diastolic filling parameters and mitral regurgitation required evaluation.
Does the WiSE-CRT system improve diastolic parameters and mitral regurgitation in patients receiving biventricular pacing?
Cohort (n=87)
Yes
Does the WiSE-CRT system improve diastolic parameters and mitral regurgitation in patients receiving biventricular pacing?
The WiSE-CRT system significantly improves aggregate assessments of diastolic function and mitral regurgitation at 6 months, extending its known benefits on left ventricular volumes and systolic function.
Answers are grounded in this paper and cite their sources.
May extend WiSE-CRT benefits to diastolic function and MR; leaves open randomized confirmation of clinical impact.
Background The WiSE-CRT system offers an innovative approach to biventricular pacing in individuals who previously were considered too high risk or had failed traditional transvenous CRT therapy. The impact on LV volumes and systolic function have previously been published. This study evaluates the impact of the WiSE CRT system on diastolic filling parameters and mitral regurgitation. Methods Retrospective cohort study of patients in SOLVE-CRT with device implantation, activated CRT therapy, and a 6-month follow-up TTE. Baseline and 6-month parameters of diastolic function and mitral regurgitation were evaluation. Most patients had sufficient data for analysis. A sub-group analysis examined results in ischemic and non-ischemic cardiomyopathies. Results Individual parameters of diastolic function and mitral regurgitation trended towards improvement at 6-months. Summative classification of diastolic function and mitral regurgitation both showed statistically significant improvement at 6-months follow-up ( p < 0.01). Conclusion In addition to the established improvement in LV volumes and LV EF, patients with the WiSE-CRT biventricular pacing system demonstrate improvement in aggregate assessment of diastolic function and mitral regurgitation at 6-months.
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Wilson et al. (2026) conducted a cohort in Heart failure requiring cardiac resynchronization therapy (n=87). WiSE-CRT system (ultrasound-based left ventricular endocardial pacing) vs. Baseline (pre-implantation) was evaluated on Proportion of patients with Grade I diastolic dysfunction (p=0.001). The WiSE-CRT biventricular pacing system significantly improved aggregate assessment of diastolic function and mitral regurgitation severity at 6 months compared to baseline.
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