Feasibility, safety, and short-term outcome of leadless ultrasound-based endocardial left ventricular resynchronization in heart failure patients: results of the Wireless Stimulation Endocardially for CRT (WiSE-CRT) study
Why the study?
Does leadless ultrasound-based left ventricular endocardial resynchronization improve QRS duration and left ventricular ejection fraction in heart failure patients?
Population
17 heart failure patients categorized as: failed coronary sinus lead implantation for CRT, non-responders to…
Design
Cohort
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
May support endocardial resynchronization proof-of-concept in HF; leaves open safety and randomized efficacy versus conventional CRT.
Structured PICO
Does leadless ultrasound-based left ventricular endocardial resynchronization improve QRS duration and left ventricular ejection fraction in heart failure patients?
P
Population
17 heart failure patients categorized as: failed coronary sinus lead implantation for CRT (n=7), non-responders to previously implanted CRT (n=2), and standard CRT indications with previously implanted pacemaker or ICD (n=8).
I
Intervention
Leadless ultrasound-based technology for left ventricular endocardial resynchronization (WiSE-CRT system)
O
Outcome
Feasibility (system implantation success, pacing thresholds), safety (pericardial effusion), and short-term outcomes (biventricular pacing percentage, QRS duration, functional class, LVEF) at 1 and 6 monthssurrogate
Leadless ultrasound-based left ventricular endocardial pacing is feasible and improves QRS duration and LVEF in heart failure patients, though safety concerns such as pericardial effusion require further investigation.
Limitations
- Small sample size
- Further study required to definitively conclude safety and performance
Cite This Study
Auricchio et al. (2014) studied this question.