Key result
Thrombin shows concentration-dependent CNS effects, switching from neuroprotective at low levels to pathological at high levels.
Why the study?
Greater attention is warranted regarding the involvement of thrombin in normal and pathological processes in the central nervous system.
Thrombin has a concentration-dependent, pleiotropic role in the central nervous system, influencing both neuroprotection and the pathogenesis of conditions like stroke, neurodegeneration, and trauma.
Alerts clinicians to CNS effects of thrombin modulation; leaves open precise therapeutic windows for neuroprotection.
-activated allosteric serine protease of the chymotrypsin family involved in coagulation, inflammation, cell protection, and apoptosis. Increasingly, the role of thrombin in the brain has been explored. Low concentrations of thrombin are neuroprotective, while high concentrations exert pathological effects. However, greater attention regarding the involvement of thrombin in normal and pathological processes in the central nervous system is warranted. In this review, we explore the mechanisms of thrombin action, localization, and functions in the central nervous system and describe the involvement of thrombin in stroke and intracerebral hemorrhage, neurodegenerative diseases, epilepsy, traumatic brain injury, and primary central nervous system tumors. We aim to comprehensively characterize the role of thrombin in neurological disease and injury.
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Shlobin et al. (2021) conducted a review in Central Nervous System Injury and Disease. Thrombin was evaluated. Thrombin exerts concentration-dependent effects in the central nervous system, with low concentrations providing neuroprotection and high concentrations promoting pathological processes.
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