Key result
Direct thrombin inhibitors and PAR blockers show potential to control thrombosis, atherogenesis, and neuroinflammation.
This review summarizes the multifaceted roles of thrombin in hemostasis and neurology, highlighting the therapeutic potential of targeting thrombin and its receptors in vascular neurology.
May support trial exploration of thrombin inhibitors in vascular neurology; leaves open clinical adoption pending randomized data.
The review presents the main physiological functions of thrombin. The procoagulant and anticoagulant activities of the key serine protease are discussed in both physiological and pathological conditions of hemostasis. The involvement of thrombin in atherogenesis, as well as its role as a mediator of vascular dysfunction and inflammation in both the peripheral and central nervous system, is highlighted. A pronounced imbalance between the pro- and anticoagulant systems leads to an increase in thrombin formation and creates conditions for the development of thrombosis. Tests that allow direct or indirect assessment of thrombin's functional activity are presented. The potential applications of direct thrombin inhibitors and direct blockers of thrombin PAR receptors in vascular neurology are also considered.
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Chan et al. (2024) conducted a review in Thrombosis and vascular neurology. Direct thrombin inhibitors and PAR receptor blockers was evaluated. Direct thrombin inhibitors and PAR receptor blockers have potential applications in vascular neurology for controlling thrombin-mediated thrombosis, atherogenesis, and neuroinflammation.
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