Key result
In-vitro tensile testing of human coronary arteries demonstrated that circumferential tensile strength and elbow stress decrease monotonically with age.
In-vitro tensile testing of human coronary arteries demonstrates that circumferential tensile strength and elbow stress decrease with age, providing biomechanical data relevant for optimizing angioplasty and bypass grafting.
Age-related arterial weakening may inform device selection; leaves open in-vivo clinical relevance.
The lack of reliable mechanical data on coronary arteries and, more specifically, on their wall strength hampers the application of numerical models and simulations to vascular problems, and precludes physicians from knowing in advance the response of coronary arteries to the different interventions. Studies of the mechanical properties of coronary arteries have been carried out almost exclusively on animals. Only a few studies have tried to characterize the in vivo behavior of human coronaries through tests under physiological conditions. In this work, the mechanical properties of human coronary arteries have been characterized. Whole samples from human right (RC) and left anterior descending (LAD) coronary arteries aged between 23 and 83 years have been studied by means of in-vitro tensile testing up to failure.
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Claes et al. (2010) studied Healthy coronary arteries (n=5). In-vitro tensile testing was evaluated on Circumferential tensile strength and elbow stress. In-vitro tensile testing of human coronary arteries demonstrated that circumferential tensile strength and elbow stress decrease monotonically with age.
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