Key result
Isolated coronary arterial smooth muscle displays a classical relationship between length, force, and velocity that changes with duration of activity and is affected by changes in length or load.
Population
Strips of isolated coronary arteries
Comparison
Contraction induced by an increase in… vs Relaxed preparations; varying loads and lengths
Design
Preclinical
Authors
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Warrants caution against clinical extrapolation; extends dynamic modeling of coronary smooth muscle in research.
The mechanical properties of coronary arterial smooth muscle, including length-force-velocity relationships, are dynamic and depend on the duration of activity and changes in length or load.
Mey et al. (1984) studied this question. Increase in extracellular potassium concentration and load clamping vs. Relaxed or resting preparations was evaluated on Mechanical properties (shortening velocity vs. length and load). Isolated coronary arterial smooth muscle displays a classical relationship between length, force, and velocity that changes with duration of activity and is affected by changes in length or load.
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