What question did this study set out to answer?

To measure the dynamic mechanical and elastic properties of smooth muscle cells in isolated arterial resistance vessel walls.

February 1, 1978The Journal of PhysiologyOpen Access

Mechanical properties of smooth muscle cells in the walls of arterial resistance vessels.

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Population

Arterial resistance vessels (internal diameter 83-235 micrometer)

Design

Preclinical

Authors

WHW HalpernUniversity of Vermont MMMichael J. MulvanyVascular / Pulmonary Vascular DWDavid M. WarshawUniversity of Vermont

Discussion

Member takes

Implication

Animal vessel mechanics require in vivo confirmation; leaves open series compliance effects on vascular tone.

Key Points

To measure the dynamic mechanical and elastic properties of smooth muscle cells in isolated arterial resistance vessel walls.
Measured dynamic mechanical responses in isolated arterial resistance vessels (internal diameter 83–235 µm) with a 4-millisecond time resolution.
Evaluated isometric force generation, isotonic shortening velocity, quick releases, and 0.3% square-wave circumference changes across varying calcium concentrations and temperatures.
Smooth muscle cells produced an isometric force of ~350 mN/mm² and achieved a maximum shortening velocity of ~0.17 lengths/sec at 37°C, exhibiting an approximately exponential instantaneous elastic profile.
Active dynamic stiffness was directly proportional to active wall tension and temperature-independent, while active half-response time was proportional to tension with a temperature coefficient (Q10) of ~1.8.
Wall tension responses to step changes in circumference were proportional to the logarithm of elapsed time, consistent with crossbridge mechanics operating in series with a compliant passive component.

Structured PICO

Population

Arterial resistance vessels (internal diameter 83-235 micrometer)

Intervention

Measurement of dynamic mechanical response under varying conditions (isometric, isotonic, quick releases, square wave changes, varying Ca2+ concentration)

Outcome

Dynamic mechanical response of smooth muscle cells (force, velocity, elasticity, wall tension, stiffness)surrogate

The mechanical responses of arterial resistance vessels reflect the properties of individual smooth muscle cells, suggesting a relatively compliant passive component in series with crossbridges.

Cite This Study

Halpern et al. (1978) studied this question.

synapsesocial.com/papers/6a8443a085a95bb87468cbb3 https://doi.org/10.1113/jphysiol.1978.sp012179

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Mechanical properties of smooth muscle cells in the walls of arterial resistance vessels.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Mechanical properties of smooth muscle cells in the walls of arterial resistance vessels.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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