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July 1, 1994The Journal of Experimental MedicineOpen Access

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.

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Authors

MKMarek KubinAmgen (United States)MKMalek KamounHospital of the University of Pennsylvania
Giorgio Trinchieri
Giorgio TrinchieriThe Wistar Institute

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Cite This Study

Kubin et al. (1994) studied this question.

synapsesocial.com/papers/6a1c67c7ecffbcc5fca14b25https://doi.org/10.1084/jem.180.1.211
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.1991 · 1,955 citations
  2. 2Gamma interferon and lymphotoxin, released by activated T cells, synergize to inhibit granulocyte/monocyte colony formation.1986 · 124 citations
  3. 3Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.1992 · 1,162 citations
  4. 4CD28-stimulated IL-2 gene expression in jurkat T cells occurs in part transcriptionally and is cyclosporine-A sensitive1992 · 36 citations
  5. 5Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.1987 · 795 citations