What does this research mean for the field?

The cardiac troponin C subunit possesses intrinsic molecular properties that mediate the length-induced increase in calcium sensitivity and myocardial performance, providing a molecular basis for Starling's law of the heart. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine the molecular mechanism underlying Starling's law of the heart by evaluating the role of troponin C in length-dependent calcium sensitivity and myocardial performance.

April 1, 1988Science

Molecular Basis for the Influence of Muscle Length on Myocardial Performance

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Population

Isolated demembranated cardiac muscle

Comparison

Substitution of cardiac troponin C with skeletal… vs Cardiac troponin C

Design

Preclinical

Authors

ÁBÁrvind BabuAlbert Einstein College of Medicine ESEdmund H. SonnenblickUniversity of Parma JGJagdish GulatiAlbert Einstein College of Medicine

Discussion

Member takes

Implication

Cardiac troponin C may mediate length-dependent activation; leaves open therapeutic targeting of Starling's law in humans.

Key Points

To determine the molecular mechanism underlying Starling's law of the heart by evaluating the role of troponin C in length-dependent calcium sensitivity and myocardial performance.
Measured Ca2+ sensitivity during tension development in isolated demembranated cardiac muscle fibers.
Substituted endogenous cardiac troponin C with skeletal troponin C and compared contractile performance at sarcomere lengths of 1.9 and 2.4 micrometers.
Enhancement of myocardial performance at the extended sarcomere length of 2.4 micrometers was greatly suppressed after substituting cardiac troponin C with skeletal troponin C.
Identified that the cardiac troponin C subunit contains intrinsic molecular properties necessary for length-induced autoregulation and actin filament activation.

Structured PICO

Population

Isolated demembranated cardiac muscle

Intervention

Substitution of cardiac troponin C with skeletal troponin C

Comparator

Cardiac troponin C

Outcome

Ca2+ sensitivity during tension development at different sarcomere lengths (1.9 and 2.4 micrometers)surrogate

The cardiac troponin C subunit possesses intrinsic properties that mediate length-dependent activation of myocardial performance, providing a molecular mechanism for Starling's law of the heart.

Cite This Study

Babu et al. (1988) studied this question.

synapsesocial.com/papers/6a1c6eef973ffece4bc3cf9a https://doi.org/10.1126/science.3353709

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Molecular Basis for the Influence of Muscle Length on Myocardial Performance

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Molecular Basis for the Influence of Muscle Length on Myocardial Performance

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider