January 27, 2006European Heart Journal
Prognostic value of coronary artery calcium screening in asymptomatic smokers and non-smokers
Key result
Coronary artery calcium scoring strongly predicted 5-year survival, which ranged from 99.5% to 81.4% in smokers and 99.7% to 89.6% in non-smokers for scores of 0-10 to >1000 (P<0.0001).
Why the study?
Does coronary artery calcium screening predict 5-year all-cause mortality in asymptomatic smokers and non-smokers?
Population
10,377 asymptomatic individuals from a referred patient registry, including 40% current smokers.
Comparison
Coronary artery calcium (CAC) screening vs Comparison across CAC score strata and smoking…
Design
Cohort
Follow-up
5 years
Authors
Discussion
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Implication
CAC scoring refines mortality risk stratification in asymptomatic adults; leaves open whether it guides interventions improving outcomes.
Study Design
Type
Cohort (n=10,377)
Structured PICO
Does coronary artery calcium screening predict 5-year all-cause mortality in asymptomatic smokers and non-smokers?
P
Population
10,377 asymptomatic individuals from a referred patient registry, including 40% current smokers.
I
Intervention
Coronary artery calcium (CAC) screening
C
Comparator
Comparison across CAC score strata (e.g., 0-10 vs >1000) and smoking status (smokers vs non-smokers)
O
Outcome
Death from all-causes at 5 yearshard clinical
Main Result
Absolute Event Rate: 96.9% vs 98.4%
p-value: p=<0.0001
Cite This Study
Shaw et al. (2006) conducted a cohort in Asymptomatic individuals (n=10,377). Current smoking vs. Non-smoking was evaluated on Cumulative 5-year survival (p=<0.0001). Coronary artery calcium scoring strongly predicted 5-year survival, which ranged from 99.5% to 81.4% in smokers and 99.7% to 89.6% in non-smokers for scores of 0-10 to >1000 (P<0.0001).