Key result
Inflammatory cardiomyopathy is linked to a ~30% transcardiac reduction in circulating mesenchymal stromal cells.
Population
29 patients undergoing endomyocardial biopsy for suspected cardiomyopathy, divided into those with and…
Design
Cross-sectional, Echocardiographic measurements were analysed independently in…
Authors
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Does not support practice changes; hypothesis-generating for MSC homing as therapeutic target in inflammatory cardiomyopathy.
Observational (n=29)
No
p-value: p=<0.01
Endogenous mesenchymal stromal cells continuously migrate to the heart in patients with inflammatory cardiomyopathy, a process strongly predicted by cardiac SDF-1α expression.
Schmidt‐Lucke et al. (2015) conducted an observational in Inflammatory cardiomyopathy (n=29). Cardiac inflammation vs. No cardiac inflammation was evaluated on Transcardiac reduction of circulating mesenchymal stromal cells (p=<0.01). Patients with inflammatory cardiomyopathy demonstrated a significant 29.9% transcardiac reduction of circulating mesenchymal stromal cells compared to those without inflammation.
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