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June 10, 2012CirculationOpen Access

Myocardial CXCR4 Expression Is Required for Mesenchymal Stem Cell Mediated Repair Following Acute Myocardial Infarction

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Why the study?

Does mesenchymal stem cell administration improve cardiac function and repair in mice following acute myocardial infarction, and is this dependent on myocardial CXCR4 expression?

Population

Conditional cardiac myocyte CXCR4 null mice and wild-type littermates subjected to acute myocardial infarction

Comparison

100,000 mesenchymal stem cells administered via… vs Saline administered via tail vein

Design

Preclinical

Follow-up

4, 7, and 21 days

Authors

FDFeng DongShandong Center for Disease Control and PreventionJHJames E. HarveyWellSpan York HospitalAFAmanda FinanUniversité de Montpellier

Discussion

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Member takes

Implication

MSC benefit in murine post-MI repair requires myocyte CXCR4; leaves open translation to human cell therapy trials.

Structured PICO

Does mesenchymal stem cell administration improve cardiac function and repair in mice following acute myocardial infarction, and is this dependent on myocardial CXCR4 expression?

P
Population
Conditional cardiac myocyte CXCR4 (CM-CXCR4) null mice and wild-type littermates subjected to acute myocardial infarction
I
Intervention
100,000 mesenchymal stem cells (MSC) administered via tail vein 1 day after acute myocardial infarction
C
Comparator
Saline administered via tail vein
O
Outcome
Ejection fraction, apoptosis (TUNEL-positive cardiac myocytes), cardiac progenitor cell recruitment, cardiac myosin-positive area, and vascular densitysurrogate

Mesenchymal stem cell-mediated cardiac repair following acute myocardial infarction requires cardiac myocyte CXCR4 expression to achieve functional benefits.

Cite This Study

Dong et al. (2012) studied this question.

synapsesocial.com/papers/6a8491cd165e087ca0f3060bhttps://doi.org/10.1161/circulationaha.111.082453
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Also Consider

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  1. 1Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)2002 · 2,211 citations
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  3. 3Stromal Cell–Derived Factor-1α Confers Protection Against Myocardial Ischemia/Reperfusion Injury2007 · 321 citations
  4. 4Stromal Cell–Derived Factor-1α Is Cardioprotective After Myocardial Infarction2008 · 238 citations
  5. 5Restoration of Cardiac Progenitor Cells After Myocardial Infarction by Self-Proliferation and Selective Homing of Bone Marrow–Derived Stem Cells2005 · 236 citations